Badania in vitro wplywu lekow przeciwrobaczych na aktywnosc enzymow trawiennych w wyciagach z jelita Ascaris suum i trzustki wieprzowej

The effect of eight anthelmintics (Rintal, Fenbesan, Telmin, Banminth, Pyrantel, Nilverm, Levamisol and Bioscardina) on the α- and γ-amylases, trypsin, and lipase from pig's pancreas and gut of Ascaris suum was determined. In extracts from A. suum gut also the maltase, trehalase and saccharase activities were examined. All drugs tested did not influence on the host's α-amylase. Telmin and Bioscardina were inhibitors of γ-amylase, Rintal and Telmin - of trypsin, Fenbesan and Bioscardina - of lipase from pig's pancreas. Among the parasite's enzymes the lipase was the most sensitive. Its activity was decreased (35-60%) by Telmin, Nilverm and both pyrantel derivatives. The activity of maltase and trehalase was reduced by Levamisol and Banminth, that of saccharase by Levamisol. It is concluded that the anthelmintics Levamisol and Banminth seemed the most efficient among the tested drugs because they did not alter the activity of host's enzymes and, showed the inhibitory effect on three of parasite's enzymes.