Synthesis and characterization of diversely substituted pyrimidine-3-carboxamide and their antimicrobial evaluation

Pyrimidine related fused heterocycles are attracted to every chemist during the last decade for their biological and chemotherapeutic importance. Pyrimidine derivatives play a vital role in their broad spectrum of biological activities including antituberculosis, anticonvulsant, anti-inflammatory, insecticidal, antifungal, analgesic, and antitumor properties and there of interest as potential bioactive molecules. The nitrogen-containing fragment may be an amidine, urea, thiourea, or guanidine, and adamantine homologs and aromatic aldehyde serve as an excellent illustrative example in that it readily undergoes as Biginali MCRs reaction. Pyrimidines and their derivatives are considered to be important for drugs and agricultural chemicals. Pyrimidine derivatives possess several interesting biological activities. Pyrimidine is a basic nucleus in DNA & RNA, it is associated with diverse biological activities so, we have designed and prepared a novel highly functionalized pyrimidine library of 1,4 DHP and DHPM via a one-pot multi-component (MCRs) synthesis and we screened for antimicrobial activity against various strains.