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Tytuł pozycji:

Exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals, New York State, USA – an 18-year population-based study

Tytuł:
Exocrine pancreatic cancer and living near to waste sites containing hazardous organic chemicals, New York State, USA – an 18-year population-based study
Autorzy:
Weinstein, Bayarmagnai
da Silva, Alan
Carpenter, David O.
Tematy:
benzene
pancreatic cancer
pesticides
residential exposure
VOCs
PCBs
Data publikacji:
2022-08-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Język:
angielski
Prawa:
CC BY-NC: Creative Commons Uznanie autorstwa - Użycie niekomercyjne 3.0 PL
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 4; 459-471
1232-1087
1896-494X
Dostawca treści:
Biblioteka Nauki
Artykuł
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ObjectivesThe etiology of exocrine pancreatic cancer (EPC) remains unknown except for family history and smoking. Despite recent medical advances, rates of pancreatic cancer incidence and mortality are increasing. Although existing evidence suggests a potentially causal relationship between environmental chemical exposures and pancreatic cancer, whether residential exposure impacts pancreatic cancer rates remains unknown.Material and MethodsThe authors identified 28 941 patients diagnosed with exocrine pancreatic cancer in New York State exclusive of New York City for the years 1996–2013. Descriptive statistics and negative binomial regression were used in this ecological study to compare pancreatic cancer hospitalization rates among patients who lived in zip codes with hazardous waste sites (HWSs) containing persistent organic pollutants (POPs) and volatile organic pollutants (VOCs) compared with clean zip codes with no identified hazardous waste sites. The authors assessed the effect of selected known and suspected human carcinogens on the EPC hospitalization rates by subgroup analyses.ResultsCompared with the clean sites, the pancreatic cancer hospital discharge rate in the “VOCs without POPs” and “VOCs and POPs” sites, after adjustment for potential confounders were 1.06 (95% CI: 1.03–1.09) and 1.05 (95% CI: 1.01–1.08), respectively. In the analysis by specific chemicals, rate ratios (RR) for the benzene (RR = 1.12) and ethylbenzene (RR = 1.34) in the non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and tetrachloroethylene (RR = 1.11) in the chlorinated VOCs group, chlorinated pesticides (RR = 1.11) and PCBs (RR = 1.05) in the POPs groups were statistically significant (p-values <0.05) compared with clean sites.ConclusionsCompared with the clean sites, the pancreatic cancer hospital discharge rate in the “VOCs without POPs” and “VOCs and POPs” sites, after adjustment for potential confounders were 1.06 (95% CI: 1.03–1.09) and 1.05 (95% CI: 1.01–1.08), respectively. In the analysis by specific chemicals, rate ratios (RR) for the benzene (RR = 1.12) and ethylbenzene (RR = 1.34) in the non-chlorinated VOCs group, trichloroethylene (RR = 1.07) and tetrachloroethylene (RR = 1.11) in the chlorinated VOCs group, chlorinated pesticides (RR = 1.11) and PCBs (RR = 1.05) in the POPs groups were statistically significant (p-values <0.05) compared with clean sites.

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